Antisense Uchl1, a long non-coding RNA that is an antisense transcript for the Uchl1 gene, upregulates UCHL1 protein levels through the combined action of an overlapping sequence at its 5′ end Antisense oligonucleotides. Antisense oligonucleotides (ASOs) are oligonucleotides that induce gene silencing. Typically, ASOs are 15–22 nucleotides in length and are designed to bind complementary RNA targets, ultimately facilitating their degradation via the RNase H pathway. Our well-established expertise in oligo synthesis makes us a Abstract. Development of intracellular delivery methods for antisense DNA and siRNA is important. Previously reported methods using liposomes or receptor-ligands take several hours or more to deliver oligonucleotides to the cytoplasm due to their retention in endosomes. Oligonucleotides modified with low molecular weight disulfide units at a 1. Introduction. Antisense oligonucleotides (ASO) are short, modified single-stranded DNA, RNA, or hybrid DNA-RNA sequences that bind complementary cellular RNAs, such as (pre-)mRNAs, or noncoding RNAs, such as microRNAs, thereby influencing their further processing. .

what is antisense dna